Publications

Chikungunya
  1. Dobbs JE, Tritsch SR, Encinales L, Cadena A, Suchowiecki K, Simon G, Mores C, Insignares S, Orozco VPV, Ospino M, Echavez LA, Gomez CAH, Crespo YG, Amdur R, Jimenez ADC, Hernandez CAP, Zapata JCM, Hernandez AS, Silvera PB, Rosales W, Mendoza E, Osorio-Llanes E, Castellar J, Jimenez D, Cooper DM, Firestein GS, Martins K and Chang AY (2022) Regulatory T-cells and GARP expression are decreased in exercise-associated chikungunya viral arthritis flares. Front. Immunol. 13:1007106. doi: 10.3389/fimmu.2022.1007106
     
  2. Tritsch SR, Porzucek AJ, Schwartz AM, Proctor AM, Amdur R, Latham PS, Simon GL, Mores CN, Chang AY. Effects of IL2/anti-IL2 antibody complex on chikungunya virus-induced arthritis in a mouse model. Sci Rep. 2023 May 5;13(1):7307. PMID: 36778306; PMCID: PMC9915476.
     
  3. Chang AY, Tritsch SR, Herrera Gomez CA, Encinales L, Cadena Bonfanti A, Rosales W, et al.(2024) Cytokine and T cell responses in post-chikungunya viral arthritis: A cross-sectional study. PLoS ONE 19(3): e0299521. https://doi.org/10.1371/journal.pone.0299521
     
  4. Chang AY, Hernández AS, Mejía JF, Tritsch SR, Mendoza-Torres E, Encinales L, et al. The Natural History of Post-Chikungunya Viral Arthritis Disease Activity and T-cell Immunology: A Cohort Study. J Cell Immunol. 2024;6(2):64-75.
     
  5. Chang, A.Y., Martins, K., Encinales, L., Reid, S.P., Acuña, M., Encinales, C., Matranga, M., Pacheco, N., Cure, C., Shukla, B., Arteta, T.R., Amdur, R., Cazares, L., Gregory, M., Ward, M., Porras, A., Mendoza, A.R., Dong, L., Kenny, T., Brueggemann, E., Downey, L., Kamalapathy, P., Lichtenberger, P., Falls, O., Simon, G.L., Bethony, J.M. and Firestein, G.S. (2017). Cross-sectional analysis of chikungunya arthritis patients 22-months post-infection demonstrates a lack of detection of viral persistence in synovial fluid. Arthritis and Rheumatology, 70(4), 585-593. https://www.ncbi.nlm.nih.gov/pubmed/29266856 PMID: 29266856
     
  6. Chang, A.Y., Encinales, L., Porras, A., Pachecho, N., Reid, S.P., Martins, K.A., Pacheco, S., Bravo, E., Navarno, M., Rico, A., Amdur, R., Kamalapathy, P., Firestein, G.S., Bethony, J.M. and Simon, G.L. (2017). Frequency of Chronic Joint Pain following Chikungunya Infection: A Colombian Cohort Study. Arthritis and Rheumatology, 70(4), 578-584. PMID: 29266783.
     
  7. Chang, A.Y., Tritsch, S., Reid, S.P., Martins, K., Encinales, L., Pacheco, N., Amdur, R.L., Porras-Ramirez, A., Rico-Mendoza, A., Li, G., Peng, G., Firestein, G.S., Simon, G.L., and Bethony, J.M. (2018). The cytokine profile in acute chikungunya infection is predictive of chronic arthritis 20 months post infection. Diseases, 6(4), 95. PMID: 30347791
     
  8. Poon, A., Simon, G., and Chang, A.Y. (Feb 2019). Treatment of chronic chikungunya with methotrexate. Journal of Clinical Rheumatology. PMID: 30720703
     
  9. Martins, K., Gregory, M., Valdez, S., Sprague, T., Encinales, L., Pacheco, N., Cure, C., Porras-Ramírez, A., Rico Mendoza, A., Chang, A.Y., Pitt, M., Nasar, F (June 2019). Neutralizing antibodies from convalescent chikungunya virus patients can cross-neutralize Mayaro and Una viruses. American Journal of Tropical Medicine and Hygiene. PMID: 3101708
     
  10. Tritsch, S.R., Encinales, L., Pacheco, N., Cadena, A., Cure, C., McMahon, E., Watson, H., Porras Ramirez, A., Rico Mendoza,  A., Li, G., Khurana, K., Jaller, J.J., Mejia Castillo, S., Barrios Taborda, O., Jaller Char, A., Avendaño, L., Jimenez, D.,  Gonzalez Coba, A., Alarcon Gomez, M., Ariza Orozco, D., Bravo, E., Martinez, V., Guerra, B., Simon, G.,  Firestein, G.S., and Chang, A.Y. (July 2019). Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms. Journal of Rheumatology, 46(8). PMID:31263071
     
  11. Watson H, Tritsch S, Encinales S, Cadena A, Cure C, Porras Ramirez A, Rico Mendoza A, Chang AY. (May 2020). Stiffness, pain, and joint counts in chronic chikungunya disease: relevance to disability and quality of life. Clinical Rheumatology. 39(5):1679-1686. PMID: 31916107
     
  12. Nogueira Hayd, R.L., Rodrigues Moreno, M., Naveca, F., Amdur, R., Suchowiecki, K.,Watson, H., Firestein, G.S., Simon, G. and  Chang, A.Y. (March 2020).  Persistent chikungunya arthritis in Roraima, Brazil. Clinical Rheumatology. PMID:32170487
     
  13. Suchowiecki K, Reid SP, Simon GL, Firestein GS, and Chang AY Persistent Joint Pain Following Arthropod Virus Infections (April 2021). Current Rheumatology Reports. 23(4):26. PMID:33847834.
     
  14. Tritsch SR, Amdur R, Encinales L, Cadena A, Fierbaugh P, Avendaño G, Gomez CAH, Suchowiecki K, Mendoza-Torres E, Rosales W, Jimenez D, Hernandez CAP, Hernandez AS, Silvera PB, Crespo YG, Jimenez ADC, Zapata JCM, Mores CN, Firestein GS, Simon G, Chang AY. Sleep Disturbances are a Significant Predictor of Chikungunya Arthritis Flare Severity. J Cell Immunol. 2021;3(3):191-197. doi: 10.33696/immunology.3.098. PMID: 34322686; PMCID: PMC8315573.  
  15. O’Driscoll M, Salije H, Chang AY, Watson H. Arthralgia resolution rate following chikungunya virus infection (Sept 2021). International Journal of Infectious Disease. 112:1-7. PMID: 34492392.
     
  16. Watson H, Nogueira‑Hayd RL, Rodrigues‑Moreno M, Naveca F, Calusi G, Suchowiecki K, Firestein GS, Simon G & Chang AY. Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis. Nature Scientific Reports. 2021, 11:18578. https://doi.org/10.1038/s41598-021-98164-9.
     
  17. Chang AY, Tritsch SR; Porzucek AJ; Schwartz AM, Seyler-Schmidt M, Glass A, Latham PS, Reid SP, Simon GL, Mores CN. A Mouse Model for Studying Post-Acute Arthritis of Chikungunya. Microorganisms. 2021, 9:1998. https://doi.org/10.3390/microorganisms9091998
Dengue
  1. Michelle Premazzi Papa, Evelyn Mendoza-Torres, Peifang Sun, Liliana Encinales, Joseph Goulet, Gabriel Defang, Jani Vihasi, Ying Cheng, Karol Suchowiecki, Wendy Rosales, Richard Amdur, Alexandra Porras-Ramirez, Alejandro Rico-Mendoza, Carlos Herrera Gomez, Sam Nicholes, Ivan Zuluaga, Liam Halstead, Scott Halstead, Gary Simon, Kevin Porter, Rebecca M Lynch, Aileen Y Chang. Dengue NS1 antibodies are associated with clearance of viral NS1, The Journal of Infectious Diseases, 2024;, jiae299, https://doi.org/10.1093/infdis/jiae299
     
  2. Rico-Mendoza A, Porras-Ramírez A, Chang AY, Encinales L, Lynch R (June 2019). Co-circulation of dengue, chikungunya, and Zika viruses in Colombia. Rev Panam Salud Publica. 43:e49. https://doi.org/10.26633/RPSP.2019.49. PMID: 31171921
     
  3. McMahon, E., Encinales, L., Navarro Encinales, C., Vielma, S., Pacheco, N., Lil Avendaño, G., Acosta Rodríguez, S., Calderon, M., Encinales Sanabria, S., Encinales, Sanabria, L., Serrano Bernal, E., Gonzaléz Coba, A., Jiménez, D., Simon, G., and Chang, A.Y. (Oct 2019).  A Dengue Vaccine: Will It be Accepted and Is It Feasible? Lessons from Barranquilla, Colombia, and Merida, Venezuela. Microorganisms. 7(10): E458. PMID: 31623165
Zika
  1. Premazzi Papa, M.; Mantus, G.; Kabra, K.; Herrera Gomez, C.; Ward, A.; Encinales, L.; Cadena, A.; Chang, A.; Lynch, R.M. Analysis of Memory Antibody Responses in Individuals with Zika-Associated Guillain–Barré Syndrome. Viruses 2024, 16, 1704. https://doi.org/10.3390/v16111704
     
  2. Katler, K., Godiwala, P., Macri, C., Pineles, B., Simon, G., Chang A.Y.  and Ahmadzia, H. (2017). Evolution of Knowledge, Awareness, and Practices Regarding Zika Virus from 2016 to 2017. Infectious Disease in Obstetrics and Gynecology, 2017(2), 1-13. doi: 10.1155/2017/6350602. PMID: 29348707
     
  3. Ho, C.Y., Castillo, N., Encinales, L., Porras, A., Mendoza, A.R., Tolosa, R.G., Lynch, R., Nemirovsky, A., Mantus, G., DeBiasi, R.L., Bethony, J.M., Simon, G.L., and Chang, A.Y. (2018). Case Report: Second-Trimester Ultrasound and Neuropathological Findings in Congenital Zika Virus Infection. The Pediatric Infectious Disease Journal. doi:10.1097/INF.0000000000002080 PMID: 30408008
     
  4. Chang A.Y., Lynch, R. and Martins, K.O. et al. Long-term clinical outcomes of Zika associated Guillain-Barré syndrome (2018). Emerging Microbes and Infections, 7(1), 148. PMID: 30131486. doi: 10.1038/s41426-018-0151-9
     
  5. Lynch, R.M, Mantus, G., Encinales, L., Pacheco, N., Li, G. Porras, A., Mendoza, A.R., Peng, J., Rengifo-Pardo, M., Cruz, M.M., Harris, E., Bethony, J.M., Simon, G.L., and Chang, A.Y. Augmented Zika and dengue neutralizing antibodies are associated with Guillain-Barré syndrome. (2018). J Infect Dis. PMID: 30113672
     
  6. Naveca, F.G., Pontes, G.S., Chang, A.Y., Villarouco da Silva, G.A., Alves do Nascimento, V., Cristina da Silva Monteiro, D., Souza da Silva, M., Abdall, L.F., Santos, J.H.A., Pires de Almeida, T.A., Contreras Mejía, M.C., Ramos de Mesquita, T.G., Valeria de Souza Encarnação, E., de Souza Gomes, M., Amaral, L.R., Campi-Azevedo, A.C. Coelho-dos-Reis, J.G., Vale Antonelli, L.R., Teixeira-Carvalho, A., Martins-Filho, O.A., and Ramasawmy, R. (May 2018). The Immunological Biomarker Profile During Acute Zika Virus Infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage. Mem Inst Oswaldo Cruz. 113(6), e170542. PMID: 29768624
Covid-19
  1. Mendoza-Torres E, Torres F, Rosales-Rada W, Encinales L, Avendaño L, Pérez MF, Terán I, Vergara D, Osorio-Llanes E, Fierbaugh E, Villamizar W and Chang AY. COVID-19 Transmission in Children: Implications for Schools. Pediatric Infectious Diseases. 2021. Doi: 10.5772/intechopen.99418
     
  2. Jairo Castellar-López, Wendy Villamizar-Villamizar, Aldo Amaranto-Pallares, Wendy Rosales-Rada, Maria De Los Angeles Vélez Verbel, Aileen Chang, Franklin Torres Jiménez and Evelyn Mendoza-Torres. Recent Insights into COVID-19 in Children and Clinical Recommendations. Current Pediatric Reviews. 2021, DOI:10.2174/1573396317666211206124347